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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
9.09
Human Site:
S225
Identified Species:
14.29
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S225
Q
N
R
S
K
H
G
S
T
N
F
I
P
E
Q
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S225
Q
N
R
S
K
H
G
S
T
N
F
I
P
E
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
N225
Q
N
R
S
K
H
G
N
T
N
F
I
P
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
N225
Q
N
R
S
K
H
G
N
T
N
F
I
P
E
Q
Rat
Rattus norvegicus
Q9JIM0
706
80103
S225
Q
N
R
S
K
H
G
S
T
N
F
I
P
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
A225
Q
N
R
S
K
H
G
A
T
N
Y
I
P
E
Q
Chicken
Gallus gallus
Q9IAM7
700
80005
A225
Q
N
R
S
K
H
G
A
T
N
Y
I
P
E
Q
Frog
Xenopus laevis
Q9W6K1
711
81112
P226
Q
N
R
S
K
H
G
P
T
N
Y
I
P
E
Q
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
F212
R
E
D
E
D
G
W
F
N
M
F
V
I
H
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
D213
E
N
V
A
N
G
E
D
G
N
E
S
K
E
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
H278
N
R
P
R
R
A
M
H
R
S
T
G
N
F
L
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
N111
S
V
N
Y
E
D
A
N
L
N
I
D
M
P
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
H222
W
F
N
I
L
V
L
H
Q
N
R
V
K
S
N
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
N221
Q
N
H
T
G
H
T
N
T
A
F
L
P
E
Q
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
R220
Q
N
H
Y
A
H
T
R
T
S
Y
V
A
E
N
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
93.3
N.A.
93.3
100
N.A.
86.6
86.6
86.6
13.3
N.A.
20
N.A.
0
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
93.3
26.6
N.A.
40
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
6.6
53.3
33.3
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
73.3
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
7
7
14
0
7
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
7
7
0
7
0
0
0
7
0
0
0
% D
% Glu:
7
7
0
7
7
0
7
0
0
0
7
0
0
74
7
% E
% Phe:
0
7
0
0
0
0
0
7
0
0
47
0
0
7
0
% F
% Gly:
0
0
0
0
7
14
54
0
7
0
0
7
0
0
0
% G
% His:
0
0
14
0
0
67
0
14
0
0
0
0
0
7
0
% H
% Ile:
0
0
0
7
0
0
0
0
0
0
7
54
7
0
0
% I
% Lys:
0
0
0
0
54
0
0
0
0
0
0
0
14
0
0
% K
% Leu:
0
0
0
0
7
0
7
0
7
0
0
7
0
0
7
% L
% Met:
0
0
0
0
0
0
7
0
0
7
0
0
7
0
0
% M
% Asn:
7
74
14
0
7
0
0
27
7
74
0
0
7
0
14
% N
% Pro:
0
0
7
0
0
0
0
7
0
0
0
0
60
7
0
% P
% Gln:
67
0
0
0
0
0
0
0
7
0
0
0
0
0
67
% Q
% Arg:
7
7
54
7
7
0
0
7
7
0
7
0
0
0
0
% R
% Ser:
7
0
0
54
0
0
0
20
0
14
0
7
0
7
0
% S
% Thr:
0
0
0
7
0
0
14
0
67
0
7
0
0
0
0
% T
% Val:
0
7
7
0
0
7
0
0
0
0
0
20
0
0
7
% V
% Trp:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
14
0
0
0
0
0
0
27
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _